Accelerating the Implementation of Mass Spectrometry in the Clinical Lab

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EUROPE 2018

Help Us Reach Our Educational Support Goal of $40,000
Educational Travel Grants supported in part by:

Corporate Workshops

**Interested in hosting a Corporate Workshop? Click here.

Corporate Workshops provide an opportunity for MSACL conference attendees to learn more about specific applications or products of interest as presented by sponsoring vendors.

These workshops are offered at no charge to attendees. Sponsoring vendors may request that attendees register. Any hosts offering workshops on Sunday or in the AM may require registration for attendance if they are catered. The PM workshops on Wednesday and Thursday do not require registration (if there are issues regarding this on-site please contact any MSACL employee).

Corporate Workshop holders must be registered for the conference.


Workshop Assignments

Workshop Sponsors: Modify your content

Wednesday September 12
8:00 - 8:45Mozart 4-5OPEN
8:00 - 8:45Papageno HallThermo ScientificView SummaryPre-Register Now
8:00 - 8:45Paracelsus HallSCIEXView SummaryPre-Register Now
13:30 - 14:15Mozart 1-3ShimadzuView SummaryPre-Register Now
13:30 - 14:15Mozart 4-5Thermo ScientificView SummaryPre-Register Now
13:30 - 14:15Paracelsus HallAgilent TechnologiesView SummaryPre-Register Now
13:30 - 14:15Trakl HallWatersView SummaryPre-Register Now
Thursday September 13
8:00 - 8:45Mozart 4-5OPEN
8:00 - 8:45Papageno HallOPEN
8:00 - 8:45Paracelsus HallZivak TechnologiesView SummaryPre-Register Now
13:30 - 14:15Mozart 4-5OPEN
13:30 - 14:15Papageno HallTecanView Summary
13:30 - 14:15Paracelsus HallOPEN
13:30 - 14:15Trakl HallOPEN


Corporate Workshop Summaries


Wednesday September 12


@ 8:00 - 8:45 in Papageno Hall with Thermo Scientific
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Targeted Screening and Semi-Quantitation of Drugs in Plasma using High-Resolution Accurate-Mass Detection and Online Sample Preparation

Sensitive and selective analytical methods are required in clinical research and forensic toxicology to properly identify a broad range of analytes in complex matrices. The existing methods need to be constantly updated as new compounds, such as designer drugs, become readily available to the illicit drug market. Liquid chromatography coupled to mass spectrometry (LC-MS) has been widely used in this area for years. So far, the preferred detection technology has been triple quadrupole MS for its selectivity in selected reaction monitoring (SRM) mode. However, this approach suffers from the limitation of being able to perform only targeted analysis, while not being useful for unknown screening of new drugs.

Come to our educational seminar to learn more.

For Research Use Only. Not for use in diagnostic procedures.

@ 8:00 - 8:45 in Paracelsus Hall with SCIEX
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A Clinical Method for Determination of Anti-Infectious Drugs in Serum
Anders Blomgren
Associate professor at Division of Clinical Chemistry and Pharmacology, Lund University

The initiative for this work was taken by physicians from four different disciplines; intensive care, clinics for infection, thorax and transplantation. There has been an unmet need for these types of analysis and especially with short response times. A TDM wish list was produced that containing about 25 different anti-infection drugs and we agreed on starting to develop methods for 7 of them as a first step.
During this talk the following will be presented.
• Introduction
• Analytes – chemistry/properties/stability
• LC, MS and Sample prep development and problem solving
• Validation with results
• Conclusion and future

@ 13:30 - 14:15 in Mozart 1-3 with Shimadzu
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Better Ways of Working in Routine Clinical Pathology Laboratories

Healthcare is dynamic and knows no bounds and so routine clinical pathology laboratories face increasing pressures on cost, time and delivering actionable data.

At Shimadzu, we believe there's always a way to make life better. This seminar explores a few options to make a difference.

1) Neil LOFTUS - SHIMADZU Corporation, UK
Expanding the capability of mass spectrometry in routine clinical pathology – creating better ways of delivering actionable data.

2) Andrea Radeljak, Matea Ivić – KB Merkur, Croatia
Automating standardized workflows in the clinical laboratory – using the Shimadzu CLAM-2000 integrated with LC-MS/MS to help increase sample throughput and make it easier for users.

3) Sigrid BAUMGARTEN - Alsachim SAS, France
From core expertise of Stable Isotope Labelled Compounds to reagent kits for high quality LCMS data

Disclaimer: For Research Use Only. Not for use in diagnostic procedures. Not available in the USA, Canada and China.

@ 13:30 - 14:15 in Mozart 4-5 with Thermo Scientific
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Fully Automated LC-MS – Theory becomes Reality

The use of LC-MS in diagnostic pathology has been limited by the complexity of equipment, materials and skills required to establish a fully validated service. A review showed only 19% of respondents were running VitaminD using LC-MS. On the basis that this is the gold standard, a fully validated and simple-to-use mass spectrometer has been a long awaited development. This presentation shares the first practical experience of using the Thermo Scientific™ Cascadion™ SM Clinical Analyser, in a laboratory, where staff have no prior experience of using LC-MS technology.

Automated LC-MS/MS: A disruptive technology will improve the quality of care for our patients
The LC-MS/MS platform provides solutions to complex analytical problems for clinical routine laboratories. This development started decades ago and the technology has proven to deliver reliable results with unreached specificity in TDM, DoA testing, endocrine diagnostics and newborn screening. In this presentation the concept of a fully integrated and automated LC-MS/MS is described. Special focus is on features of the Thermo Scientific™ Cascadion™ SM Clinical Analyzer that can overcome the limitations of open systems.

Product IVD/CE-marked. Product not 510(k) cleared and not yet available for sale in the US.

@ 13:30 - 14:15 in Paracelsus Hall with Agilent Technologies
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Developing and Delivering Advanced Protein Biomarker Tests for an Era of Precision Medicine
Speaker: Prof. Stephen R Pennington, Senior Fellow UCD Conway Institute, University College Dublin, Ireland

This presentation will address the key issues around the development of protein signatures in areas of significant unmet clinical need and potential strategies for the delivery and implementation of multiplexed protein biomarkers in a diagnostic setting.

View abstract

For Research Use Only. Not for use in diagnostic procedures.

@ 13:30 - 14:15 in Trakl Hall with Waters
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Determination of Steroid Hormones in biological matrices by Tandem Mass Spectrometry

The determination of steroid hormones in biological matrices requires high analytical sensitivity and is particularly challenging due to analytical interferences from structurally related steroid hormones and synthetic derivatives. LC-MS/MS can provide the analytical sensitivity, selectivity and precision required to enable accurate quantification of organic compounds in human biological liquid matrices.

As a leading clinical LC-MS/MS solutions partner, Waters is a trusted provider of in vitro diagnostic medical devices, consumables, informatics, and support services for high performance LC-MS/MS systems.

Join us at this workshop to gain insights into how our customers have addressed the challenging analysis of steroid hormones by implementing Waters solutions.

LC-MS/MS Analysis of Steroids in the Clinical Laboratory
Dr. Brian Keevil, University Hospital of South Manchester , Biochemistry Department

Download Dr. Keevil's abstract

For Research Use Only. Not for use in diagnostic procedures.

Learn more on Waters Solutions for LC/MS Analysis

Thursday September 13


@ 8:00 - 8:45 in Paracelsus Hall with Zivak Technologies
Pre-Register Now
From Primary Sample Tubes to Results: World’s First Fully Automated Sample Preparation and Injection UHPLC System

Zivak Technologies is delivering solution to manual sample preparation related problems of chromatography analysis and enabling clinical laboratories to make the most of their MS/MS instruments by full automatization.

Fully automated Zivak analyzers allow you to get results from primary sample tubes without any user intervention. After the tubes are placed in the sample tray and the analysis is started on the computer, the robotic arms carry out all sample preparation steps, inject the prepared sample to MS/MS and chromatographic run starts. With Zivak analyzers, opening the sample tubes’ caps is never required.

Attend the workshop and listen a detailed review of World’s First Walk Away Sample Preparation and Injection UHPLC System Multitasker and Zivak’s Revolutionary VD-200, Fully Automated Vitamin D2-D3 UHPLC Analyzer from Prof. Dr. Ahmet Ceyhan Gören.

@ 13:30 - 14:15 in Papageno Hall with Tecan
Meet our experts in MS sample prep who will present innovative workflows using positive pressure workstations and liquid handling platforms to prep samples for clinical proteomics and steroid analysis.

Semi-automated sample processing for clinical proteomics
Stefan Loroch, Leibniz Institute for Analytical Sciences (ISAS), Proteomics Facility

Powerful automated multi-steroid extraction via positive pressure and liquid handling platform for LC-MS analysis
Dr. Christian Scherling, Tecan Germany, MS Sample Prep Application Specialist